How BPH is related to baldness. Which drug to choose?

It is widely accepted that benign prostatic hyperplasia (BPH) is a disease of old men, and in general, it corresponds to the facts. The average age of this diagnosis is 60, and more than 60% of victims are over 65.

However, the number of patients among men at the age of under 55 constantly grows. Here is why even young people should be ready to the development of the symptoms of this virulent disease. The early alopecia may be the first sign that a man is at a risk. One would think how come BPH has to do with baldness and how these diseases are related. But it turns out that both pathologies have the same origin.

Relation of BPH with alopecia

The most common type of alopecia is androgenetic one. The androgenic hormones induce a destruction of the hair follicles on the head during this disease, so that a man loses hair quickly. This type of the alopecia is usually hereditary, and the first manifestations of the baldness appear at the age under 30.  

The researchers from the National Cancer Institute (USA) have found out that the development of BPH is also related to the androgenic hormones in men and conducted full-scale clinical studies. It has been detected during these studies that a cause of both diseases is the main androgenic hormone dihydrotestosterone. It turns out that it binds by 4 times stronger with the androgenic cells, than testosterone. So, it provides a wide physiological action on the body even in small amount. But when the level of dihydrotestosterone grows, the androgenic receptors in the tissues begin to mutate, and it induces the cell proliferation of the prostatic gland. As a result, it leads to a cancer of the prostatic gland. The androgenic receptors of the hair follicles have the same sensitivity as the tissues of the prostatic gland. So, in case of the increased level of dihydrotestosterone, they also lose their main function and stop producing the hair after they fall off.  

This hormone influences on other target-organs in men: external genitals, skeletal muscles, and others. But the androgenic receptors are more resistant to the action of dihydrotestosterone in these tissues, and therefore the hair follicles and prostatic gland take the fall.     

As the benign prostatic hyperplasia may be asymptomatic for a long period, and a man will not even suspect the pathological changes in the prostatic gland. The androgenetic type of alopecia may say that dihydrotestosterone is very active as to the hair follicles and prostatic gland, and it is necessary to quickly have a medical examination. And even if the examination did not detect any changes in the prostatic gland, do not close your eyes to the potential threat. 

The androgenic baldness is not dangerous because it just an aesthetic problem. But in any case, the excessive amount of testosterone may induce the foreign tissue lesion in the prostatic gland.

The researchers from the National Cancer Institute (USA) believe that 5-alpha-reductase inhibitors should be used for the treatment of alopecia and prevention of the BPH: Finasteride (Proscar and Propecia).

  • Propecia works for men with alopecia who do not have the changes in the prostatic gland. The drug contains 1 mg Finasteride, and it will help to stop the alopecia and prevent the development of BPH.
  • Proscar has 5 mg Finasteride and is applied when the alopecia is accompanied with the increase of the prostatic gland, and there are the first manifestations of the tumor development.

What do 5-alpha-reductase inhibitors do?

  • They stop the transformation of testosterone into dihydrotestosterone.
  • They decrease the level of dihydrotestosterone by up to 89% within 72 hours.
  • They keep the low level of dihydrotestosterone within the entire course of the treatment.
  • They block the negative effect of the androgenic hormones on the cells of the target-organs, hair follicles, and tissues of the prostatic gland.

This way, the use of Finasteride removes the risk of the prostate cancer within several days.

Unfortunately, there are no analogues of the 5-alpha-reductase inhibitors today, and Finasteride remains the only medication that gives 100% results of the treatment for many years now.